How does hypothyroidism cause hyperprolactinaemia?

I was just wondering how hypothyroidism causes hyperprolactinaemia?

I thought that TRH stimulates prolactin, so if TRH is low surely prolactin should be low too?

Authored By Zahra Rabbee on Thursday 7th February 2013


Miss Luna Ibrahim
Medical Student - Warwick
Posted over 7 years ago

TRH is high in hypothyroidism.

Dopamine has the dominant influence over prolactin secretion. Secretion of prolactin is under tonic inhibitory control by dopamine, which acts via D2-type receptors located on lactotrophs. Prolactin production can