Hormone sensitive Lipase in Type 2 Diabetes mellitus

Hello.
My question is regarding the rise of NEFAs as a pathogenic cause of type 2 DM.
In a healthy human hormone sensitive lipase responds to epinephrine, ACTH & glucagon to release glycerol + NEFAs. I thought this enzyme would be the main culprit acting to release glycerol + NEFAs in DM2, however, several papers are saying it markedly reduced! My question is then, if HSL is reduced in type 2 DM/Obese patients, what enzyme is responsible for the lipolysis? Which hormone stimulates it?

I hope someone can shed some light on this.

Thanks!

Authored By m altidor on Sunday 30th December 2012

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Miss Luna Ibrahim
·
Medical Student - Warwick
·
Posted almost 7 years ago

I'm not sure if I'm shedding any light but I found this paper from October 2011 edition of Diabetes which questions the contribution of NEFAs to Insulin resistance.

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