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Www.bmj
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8

Safety of psychotropic drugs in pregnancy

Mental illness in pregnancy is common—around 10% of women experience a major depressive illness or anxiety disorder,1 and an increasing number of women with psychotic disorders are able to conceive owing to the decreased use of antipsychotics with prolactin raising properties.2 Women who have severe mental illness in the perinatal period are at risk of considerable psychological morbidity, including suicide,2 but they often discontinue psychotropics,3 largely because of concerns about safety.4 Evidence on the risks of drugs from observational data is limited and contradictory, with important methodological limitations due to bias, confounding, and small sample sizes.5 In two linked papers in this issue, Furu and colleagues (doi:10.1136/bmj.h17986 and Vigod and colleagues (doi:10.1136/bmj.h2298)7 tackle some of these limitations by using novel methods to reduce confounding in large linked datasets, and thus provide a valuable addition to the evidence base on the safety of psychotropic drugs in pregnancy.  
feeds.bmj.com
almost 6 years ago
Preview
0
4

Safety of psychotropic drugs in pregnancy

Mental illness in pregnancy is common—around 10% of women experience a major depressive illness or anxiety disorder,1 and an increasing number of women with psychotic disorders are able to conceive owing to the decreased use of antipsychotics with prolactin raising properties.2 Women who have severe mental illness in the perinatal period are at risk of considerable psychological morbidity, including suicide,2 but they often discontinue psychotropics,3 largely because of concerns about safety.4 Evidence on the risks of drugs from observational data is limited and contradictory, with important methodological limitations due to bias, confounding, and small sample sizes.5 In two linked papers in this issue, Furu and colleagues (doi:10.1136/bmj.h17986 and Vigod and colleagues (doi:10.1136/bmj.h2298)7 tackle some of these limitations by using novel methods to reduce confounding in large linked datasets, and thus provide a valuable addition to the evidence base on the safety of psychotropic drugs in pregnancy.  
feeds.bmj.com
almost 6 years ago
Www.bmj
0
17

Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study

Participants Among women who delivered a singleton infant between 2003 and 2012, and who were eligible for provincially funded drug coverage, those with ≥2 consecutive prescriptions for an antipsychotic medication during pregnancy, at least one of which was filled in the first or second trimester, were selected. Of these antipsychotic drug users, 1021 were matched 1:1 with 1021 non-users by means of a HDPS algorithm.  
feeds.bmj.com
almost 6 years ago
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0
24

Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study

Objective To provide absolute and relative risk estimates of neonatal abstinence syndrome (NAS) based on duration and timing of prescription opioid use during pregnancy in the presence or absence of additional NAS risk factors of history of opioid misuse or dependence, misuse of other substances, non-opioid psychotropic drug use, and smoking.  
feeds.bmj.com
almost 6 years ago
Preview
0
6

Safety of psychotropic drugs in pregnancy

Mental illness in pregnancy is common—around 10% of women experience a major depressive illness or anxiety disorder,1 and an increasing number of women with psychotic disorders are able to conceive owing to the decreased use of antipsychotics with prolactin raising properties.2 Women who have severe mental illness in the perinatal period are at risk of considerable psychological morbidity, including suicide,2 but they often discontinue psychotropics,3 largely because of concerns about safety.4 Evidence on the risks of drugs from observational data is limited and contradictory, with important methodological limitations due to bias, confounding, and small sample sizes.5 In two linked papers in this issue, Furu and colleagues (doi:10.1136/bmj.h17986 and Vigod and colleagues (doi:10.1136/bmj.h2298)7 tackle some of these limitations by using novel methods to reduce confounding in large linked datasets, and thus provide a valuable addition to the evidence base on the safety of psychotropic drugs in pregnancy.  
feeds.bmj.com
almost 6 years ago
Preview
0
2

Hospital practice explains variation in outcomes in extremely premature infants, US study finds

Much of the variation seen in outcomes among infants born at 22, 23, or 24 weeks of gestation can be explained by differences in hospitals’ practices on whether to initiate active treatment to save the lives of these extremely premature newborns, concludes a new study in the New England Journal of Medicine.1  
feeds.bmj.com
almost 6 years ago
Preview
2
91

Bedside Obstetrics & Gynecology

The second edition of Bedside Obstetrics & Gynecology brings postgraduate trainees fully up to date with the most recent advances in the field. The first section covers obstetrics, discussing normal and abnormal presentations (such as normal labour versus breech presentation), complications in pregnancy (including early pregnancy bleeding and ante- and postpartum haemorrhage), and medical disorders related to pregnancy (such as preeclampsia and gestational diabetes). Section two covers numerous gynaecological abnormalities. This new edition has been fully revised but continues to emphasise the importance of history taking and clinical examination. New chapters have been added to cover topics such as preterm pregnancy, post-dated pregnancy and intrauterine death, bleeding due to miscarriage, menopause and contraception. Nearly 1100 images, illustrations and tables enhance learning, and each chapter includes questions and answers related to case studies. Key points Fully revised, new edition providing recent advances in obstetrics and gynaecology Many new chapters added Includes 1100 images, illustrations and tables Previous edition published in 2010  
books.google.co.uk
over 5 years ago
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1
65

What are the different types of antenatal care available to me? / FAQs / Pregnancy information from midwivesonline.com

midwivesonline.com is the UK's leading unique midwifery led web site for midwives, health care professionals and expectant and new parents  
midwivesonline.com
over 5 years ago
Www.bmj
0
1

Antidepressants in late pregnancy are linked to respiratory disorder in newborns, study finds

Use of antidepressants in late pregnancy may be associated with a small increased risk of persistent pulmonary hypertension of the newborn (PPHN), a US study involving more than three million women published in JAMA has found.1  
feeds.bmj.com
over 5 years ago
Www.bmj
0
1

Antidepressants in late pregnancy are linked to respiratory disorder in newborns, study finds

Use of antidepressants in late pregnancy may be associated with a small increased risk of persistent pulmonary hypertension of the newborn (PPHN), a US study involving more than three million women published in JAMA has found.1  
feeds.bmj.com
over 5 years ago
Www.bmj
0
3

Antidepressants in late pregnancy are linked to respiratory disorder in newborns, study finds

Use of antidepressants in late pregnancy may be associated with a small increased risk of persistent pulmonary hypertension of the newborn (PPHN), a US study involving more than three million women published in JAMA has found.1  
feeds.bmj.com
over 5 years ago
Sinaiem dark
0
7

pregnancy-pain

A 29 y/o F 20 weeks pregnant presents with fever, dysuria, and left flank pain. She has some CVA tenderness on the right. WBC is elevated to 15. UA shows both blood and leukocytes in the urine. You are concerned about pyelonephritis vs. and infected stone. What are the risks of imaging this patient?  
sinaiem.org
over 5 years ago