New to Meducation?
Sign up
Already signed up? Log In
view moderators

Pharmacokinetics

Category

Www.bmj
0
10

The secret realm of phase I trials in healthy volunteers

Phase I clinical trials in healthy volunteers aim at establishing safety, pharmacokinetics, and dosage for subsequent testing of new drugs. They are a necessary step in building the evidence for new treatments. But many view them with suspicion. Phase I trials expose humans to unproved drugs—often at plasma concentrations needed for detecting toxicity. Because volunteers are healthy, the ratio of medical risk to benefit for them is almost infinite. Another reason for suspicion is that healthy volunteers are paid—a fact that makes it likely that primary motivations for participation are misaligned with those of researchers,1 and that study participants will be drawn from underemployed people.  
feeds.bmj.com
over 5 years ago
Preview
1
29

Critical Care

We agree with the recent commentary of Gonçalves-Pereira and Oliveira refuting a ‘one size fits all’ paradigm of antibiotic dosing in patients subjected to extracorporeal circulation [1] but want to focus somewhat further on meropenem pharmacokinetics (PK).  
ccforum.com
over 5 years ago
Preview
1
27

A Foundation for Neonatal Care

This authoritative guide offers a vital overview including the recent fundamental changes in the care of newborn babies. As well as medical staff, key roles are now played by senior nurses, clinical nurse specialists, pharmacists, advanced neonatal nurse practitioners, nurse consultants, midwives, dieticians, physiotherapists and speech therapists. The involvement of such a diverse range of professional cultures in such a rapidly developing area often leads to competing priorities, complicated by a lack of established guidelines. There is also the added challenge of fetal medicine - an important emerging allied specialty new to many healthcare professionals. This book assists all professionals involved in the provision of neonatal care in understanding the genetic, physiological and biochemical mechanisms which have either led to or are associated with the clinical conditions affecting their patients. With comprehensive chapters on fetal medicine, genetics, inherited biochemical disorders, fundamental physiological concepts, the cardiovascular, renal and respiratory systems, bacterial and transplacental infections, pharmacokinetics, nutrition, and an overview of haemostasis, A Foundation For Neonatal Care aids understanding of the continuum of developmental physiology and pathology which is now required of neonatal care providers.  
books.google.co.uk
over 5 years ago
Preview
0
28

Acetaminophen & Salicylate Toxicity with Dr. Bosse

Dr. George Bosse gives a thorough review of acetaminophen and salicylic acid pharmacokinetics followed by presenting symptoms, pathology and treatments for t...  
youtube.com
over 5 years ago
Preview
0
37

Paracetamol should remain the first line option for persistent pain

Persistent pain in older people is a serious problem that is often undermanaged.1 Osteoarthritis disproportionately affects older people, yet they are often under-represented in trials. Furthermore, their response to analgesics may differ from that of younger patients owing to altered pharmacokinetics and pharmacodynamics.2  
feeds.bmj.com
over 5 years ago
Preview
0
167

Pharmacology Introductory Principles - USMLE Tutorial

http://www.usmlesuccess.net A look at the high-yield principles of Pharmacokinetics & Pharmacodynamics - essential USMLE Step 1 information. Download your FR...  
youtube.com
almost 6 years ago
Preview
0
1

Pharmacology Introductory Principles - USMLE Tutorial - YouTube

http://www.usmlesuccess.net A look at the high-yield principles of Pharmacokinetics & Pharmacodynamics - essential USMLE Step 1 information. Download your FR...  
youtube.com
almost 6 years ago
Preview
2
63

Pharmacology Application in Athletic Training

Here's the information students need to know about how drugs work and how they can affect athletic performance. Through "real life" scenarios, students gain insights into the application of pharmacology in their clinical practice—from assisting an athlete who is taking a new medication to recognizing drug-related side effects when a negative reaction is occurring to handling instances of drug abuse. Beginning with an overview of pharmacokinetics and pharmacodynamics, the text presents prescription and over-the-counter medications in relation to the injuries or health conditions athletic trainers commonly encounter. Frequently abused substances such as amphetamines, herbals, and anabolic steroids are also addressed. Legal and ethical issues of drug use are presented, such as HIPAA–mandated privacy issues, drug testing, and which drugs are deemed as acceptable or banned according to NCAA and US Olympic standard.  
books.google.co.uk
almost 6 years ago
Preview
2
87

PHARMACOKINETICS; Absorption & Distribution of Drugs by Professor Fink

In this Video Lecture on Pharmacokinetics, Professor Fink describes the Absorption & Distribution of Drugs. The major factors affecting the systemic absorpti...  
YouTube
almost 6 years ago
Preview
2
139

Pharmacokinetics for Students: Absorption, Distribution, Metabolism, and Elimination -Lect 1

PK or pharmacokinetics, what is it? The four things will discuss are four components of PK Absorption, Distribution, Metabolism, and Elimination (ADME). Lear...  
YouTube
about 6 years ago
Preview
1
101

PHARMACOKINETICS; Absorption & Distribution of Drugs by Professor Fink

In this Video Lecture on Pharmacokinetics, Professor Fink describes the Absorption & Distribution of Drugs. The major factors affecting the systemic absorpti...  
YouTube
over 6 years ago