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Acetaminophen & Salicylate Toxicity with Dr. Bosse

Dr. George Bosse gives a thorough review of acetaminophen and salicylic acid pharmacokinetics followed by presenting symptoms, pathology and treatments for t...  
youtube.com
over 2 years ago
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42

Rubin's Pathology

Rubin's Pathology is a core textbook for medical students taking pathology. Pathology in medical school is generally taught in one of two ways: (1) as a year long course in the second year of medical school, covering principles and systems, or (2) as a two part course, beginning with fundamental principles in the first year of medical school and concluding with systems pathology in the second year of medical school. This text emphasizes concepts that a medical student needs to know without going into unnecessary detail. It features numerous high-quality images and superb four-color illustrations. A companion website offers valuable additional material to enhance learning and teaching.  
books.google.co.uk
over 2 years ago
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Methylene Blue to Identify Nerve Pathology and Guide Surgery

The authors describe a promising new technique using preoperative ultrasound-guided methylene blue administration to plan and execute peripheral nerve surgery.  
medscape.com
about 2 years ago
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6

Diagnostic Pathology

Mucinous tubular and spindle cell renal cell carcinoma is a rare, recently described variant of renal cell carcinoma characterized by an admixture of cuboidal cells in tubules and sheets of spindle cells, and variable amounts of mucinous stroma. It has been recognized as a distinct entity in the 2004 World Health Organization tumor classification. Since then, several dozen of these tumor have been reported with additional complementary morphologic characteristics, immunohistochemical profile, and molecular genetic features that have further clarified its clinicopathologic aspects. Although originally considered as a low grade renal cell carcinoma on the basis of its bland appearing nuclear features and indolent clinical course, mucinous tubular and spindle cell renal cell carcinoma has currently been proven to be a tumor that has a histological spectrum ranging from low to high grade that includes sarcomatoid differentiation. In this review, we present a detailed summary of the current knowledge regarding the clinicopathologic, immunohistochemical, molecular genetic, and prognostic characteristics, as well as differential diagnoses of mucinous tubular and spindle cell renal cell carcinoma.  
diagnosticpathology.org
about 2 years ago
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Doctor profile: Roberto Gamez, MD

Roberto Gamez, MD, MPH, a gynecologic and breast pathologist, describes how he diagnoses disease and talks about being part of the highly specialized team of...  
youtube.com
about 2 years ago
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MGH Develops Molecular Diagnostics Tool on a Smartphone |

By quantifying the number of tumor-marker-targeting microbeads bound to cells (lower images), the D3 system categorizes high- and low-risk cervical biopsy  
medgadget.com
about 2 years ago
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Paediatric Urology | Uroweb

A collaborative working group consisting of members representing the European Society for Paediatric Urology (ESPU) and the European Association of Urology (EAU) has prepared these Guidelines with the aim of increasing the quality of care for children with urological conditions. This Guidelines document addresses a number of common clinical pathologies in paediatric urological practice, but covering the entire field of paediatric urology in a single guideline document is unattainable.  
uroweb.org
about 2 years ago
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What Happens After the Scan? Dr Kenneth Bloom on Pathology, Detection and Treatment

Breast cancer awareness has come a long way. Today, the fight to find a cure and the campaign to encourage early detection has garnered support from survivors, family members, researchers and fundraisers around the world. Thanks to their efforts, most of us are now in the know and familiar with terms like “mammogram,” “early detection,” and “breast cancer screening”.  
newsroom.gehealthcare.com
about 2 years ago
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Pathologists: Medical Detectives

Pathology and laboratory medicine are the focus of an exhibit at the International Museum of Surgical Science in Chicago, Diagnostic Detectives: Pathology in...  
youtube.com
about 2 years ago
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Patient commentary: Consider the person alongside the pathology

My experience of being discussed at multidisciplinary team (MDT) meetings backs Eigenmann’s view that someone who can present the patient’s perspective should be there.1 It also suggests that patients should be alerted to these meetings and might value the option to represent themselves.  
bmj.com
about 2 years ago
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15

Tuberculous Pericarditis

A 15-year-old boy presented to the emergency department with symptoms of fever, chest tightness, epigastralgia, and progressive dyspnea for 7 days. There was neither febrile illness nor upper respiratory symptoms among family members. The patient’s grandfather had old tuberculosis but had had no close contact with the patient. The patient had bilateral rales and distant heart sound but no friction rub. Multiple nontender lymph nodes, ≈0.5 cm, were palpated at the neck and inguinal area. Cardiomegaly and blunt costophrenic angles were evident in a plain radiograph of the chest (Figure 1). An echocardiogram revealed the presence of pleural effusion, massive hypodense pericardial effusion with fibrin-like material (Figure 2A and 2B and Movie I in the online-only Data Supplement), partial collapse of the right atrium and right ventricle during diastole, and mild pericardial thickening. Under the impression of pericarditis with cardiac tamponade, he received immediate pericardiocentesis. The fluid was clear and light yellowish in appearance and was lymphocyte predominant (96%) in cell-count analysis. Gram stain, acid-fast stain, bacterial, and fungal cultures all yielded negative results. Cytology revealed no malignant cell. His influenza rapid test was positive for influenza B. However, fever persisted despite the use of antibiotics, including ampicillin-sulbactam and then piperacillin-tazobactam, oseltamivir, and doxycycline. Follow-up echocardiogram and computed tomographic scan 9 days later showed a small amount of hyperdense pericardial effusion and marked thickening (maximum, 1 cm excluding the pericardial space) of pericardium without calcification (Figures 2C, 2D, and 3 and Movie II in the online-only Data Supplement). Polymerase chain reaction (PCR) tests were negative for tuberculosis, adenovirus, pan-enterovirus, influenza A/B, and parvovirus B19. Serologies for atypical pathogens and autoimmune screening tests were all negative. Video-assisted thoracoscopic pericardial biopsy was performed, which showed pericardial thickening, ≈1 cm in thickness, with only some fibrin and whitish jelly-like content inside the pericardial space without pericardial effusion (Figure 4). Pathology showed granulomatous inflammation with caseous necrosis in hematoxylin and eosin stain and 1 acid-fast bacillus (Figure 5). Culture of the pericardial fluid and pericardial tissue both grew Mycobacterium tuberculosis. Tuberculous (TB) pericarditis was finally diagnosed, and anti-TB combination therapy was then started. The fever subsided soon, and the patient was discharged 1 week later. Plain radiograph of the chest 4 and 6 months after discharge showed normal heart size and a sharp costophrenic angle (Figure 6). Echocardiography revealed no pericardial effusion and no diastolic dysfunction 3 and 9 months after discharge (Figure 7 and Movie III in the online-only Data Supplement).  
circ.ahajournals.org
about 2 years ago
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Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington’s disease

Huntington’s disease can be predicted many years before symptom onset, and thus makes an ideal model for studying the earliest mechanisms of neurodegeneration. Diffuse patterns of structural connectivity loss occur in the basal ganglia and cortex early in the disease. However, the organizational principles that underlie these changes are unclear. By understanding such principles we can gain insight into the link between the cellular pathology caused by mutant huntingtin and its downstream effect at the macroscopic level. The ‘rich club’ is a pattern of organization established in healthy human brains, where specific hub ‘rich club’ brain regions are more highly connected to each other than other brain regions. We hypothesized that selective loss of rich club connectivity might represent an organizing principle underlying the distributed pattern of structural connectivity loss seen in Huntington’s disease. To test this hypothesis we performed diffusion tractography and graph theoretical analysis in a pseudo-longitudinal study of 50 premanifest and 38 manifest Huntington’s disease participants compared with 47 healthy controls. Consistent with our hypothesis we found that structural connectivity loss selectively affected rich club brain regions in premanifest and manifest Huntington’s disease participants compared with controls. We found progressive network changes across controls, premanifest Huntington’s disease and manifest Huntington’s disease characterized by increased network segregation in the premanifest stage and loss of network integration in manifest disease. These regional and whole brain network differences were highly correlated with cognitive and motor deficits suggesting they have pathophysiological relevance. We also observed greater reductions in the connectivity of brain regions that have higher network traffic and lower clustering of neighbouring regions. This provides a potential mechanism that results in a characteristic pattern of structural connectivity loss targeting highly connected brain regions with high network traffic and low clustering of neighbouring regions. Our findings highlight the role of the rich club as a substrate for the structural connectivity loss seen in Huntington’s disease and have broader implications for understanding the connection between molecular and systems level pathology in neurodegenerative disease.  
brain.oxfordjournals.org
about 2 years ago
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Reclassified AS Patients At Higher Risk of Adverse PCa Pathology

Rates of prostate cancer adverse pathology varied from 24% for men with more than 2 positive biopsy cores to 45% in men reclassified by Gleason score.  
renalandurologynews.com
about 2 years ago
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In Sixty - Pathologist Perspective

IN SIXTY is Manitoba’s Cancer Patient Journey Initiative aimed to get patients from suspicion of cancer, through diagnosis, and to their first treatment faster…  
vimeo.com
about 2 years ago