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16

Stronger muscles make for healthier bone development

Scientists at the University of Southampton have shown that higher muscle mass is strongly linked with healthier bone development in children.  
medicalnewstoday.com
almost 6 years ago
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31

Efforts needed to standardize criteria for age-related muscle loss

The term 'sarcopenia' is most often used to describe age-related loss in muscle mass and strength, and it is commonly considered analogous to osteoporosis.  
medicalnewstoday.com
almost 6 years ago
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Origin of cancer wasting identified in fruit flies

The progressive wasting of muscle and fat tissue throughout the body is one of the most visible and heartbreaking manifestations of cancer, yet little is known about how tumors cause distant...  
medicalnewstoday.com
almost 6 years ago
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5

Selenide protects heart muscle in the wake of cardiac arrest

Tissue damage is diminished by nearly 90 percent, finds preclinical studyDamage to heart muscle from insufficient blood supply during cardiac arrest and reperfusion...  
medicalnewstoday.com
almost 6 years ago
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6

New cystic fibrosis research could help develop treatments to improve muscle function

People suffering from cystic fibrosis have less ability to uptake and use oxygen in their muscles, which leads to exercise intolerance, a study published in Experimental Physiology...  
medicalnewstoday.com
almost 6 years ago
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12

30-year-old Russian man volunteers for world's first human head transplant

Valery Spiridonov, a 30-year-old computer scientist with a rare genetic muscle wasting disease, is to become the first person to undergo the world's first human head transplant.  
medicalnewstoday.com
almost 6 years ago
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5

Study finds testicular cancer link for muscle-building supplements

Men who reported taking muscle-building supplements, such as pills and powders with creatine or androstenedione, reported a significantly higher likelihood of having developed testicular cancer...  
medicalnewstoday.com
almost 6 years ago
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5

Cardiac and respiratory function supported by abdominal muscles in muscular dystrophy

The muscular dystrophies are known to target various muscle groups differentially.  
medicalnewstoday.com
almost 6 years ago
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7

Scientists grow leg muscle from cells in a dish

A team of researchers from Italy, Israel and the United Kingdom has succeeded in generating mature, functional skeletal muscles in mice using a new approach for tissue engineering.  
medicalnewstoday.com
almost 6 years ago
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2

Scientists develop active substance for fatal muscle wasting in male children

Duchenne muscular dystrophy is a congenital disease which causes muscle degeneration and eventual death in teenagers.  
medicalnewstoday.com
almost 6 years ago
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Five days of eating fatty foods can alter the way your body's muscle processes food, Virginia Tech researchers find

You might think that you can get away with eating fatty foods for a few days without it making any significant changes to your body. Think again.  
medicalnewstoday.com
almost 6 years ago
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5

Metabolic problems 'more likely in evening types than morning people'

According to a new study of circadian rhythms, staying up late is linked to increased risk of diabetes, metabolic syndrome, reduced muscle mass and sarcopenia.  
medicalnewstoday.com
almost 6 years ago
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4

Into thin air and back

New deer mouse study examines muscle performance and high altitude adaptationLife has adapted to all sorts of extreme environments on Earth, among them, animals like...  
medicalnewstoday.com
almost 6 years ago
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7

Therapeutic exercise lessens lung injury and muscle wasting in critically ill patients

Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that affects approximately 200,000 people a year in the United States and has a higher mortality rate than breast...  
medicalnewstoday.com
almost 6 years ago
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17

Artificial hand able to respond sensitively thanks to muscles made from smart metal wires

Engineers at Saarland University have taken a leaf out of nature's book by equipping an artificial hand with muscles made from shape-memory wire.  
medicalnewstoday.com
almost 6 years ago
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15

Trauma program recoups investment by transforming lives, Australia

Enhanced surgery to reactivate the muscles in tetraplegics' hands and housing that allows people with disabilities to live independently are just two of the transformative benefits to come out...  
medicalnewstoday.com
almost 6 years ago
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1

How does bench angle affect upper body muscle activation during bench press exercise?

Muscular activation during exercise is the key to developing muscle mass and strength and the bench press exercise is a popular and widely used method of building upper body strength.  
medicalnewstoday.com
almost 6 years ago
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3

New approach to muscle regeneration restores function after traumatic injury without need for donor tissue

Loss of muscle volume is a common and often debilitating outcome of traumatic orthopedic injury, resulting in muscle weakness and suboptimal limb function.  
medicalnewstoday.com
almost 6 years ago
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3

A strategy for stimulating heart muscle regeneration in infants, study finds

Surgery often is life-saving for many infants born with heart defects, but one thing that doctors cannot do yet is replace heart muscle that is scarred and dysfunctional.  
medicalnewstoday.com
almost 6 years ago
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2

Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth

Cell growth is orchestrated by changes in gene expression that respond to developmental and environmental cues. Among the signaling pathways that direct growth are enzymes of the protein kinase C (PKC) family, which are ubiquitous proteins belonging to three distinct subclasses: conventional PKCs, novel PKCs, and atypical PKCs. Functional overlap makes determining the physiological actions of different PKC isoforms difficult. We showed that two novel PKC isoforms, PKCδ and PKCε, redundantly govern stress-reactive and developmental heart growth by modulating the expression of cardiac genes central to stress-activated protein kinase and periostin signaling. Mice with combined postnatal cardiomyocyte-specific genetic ablation of PKCδ and germline deletion of PKCε (DCKO) had normally sized hearts, but their hearts had transcriptional changes typical of pathological hypertrophy. Cardiac hypertrophy and dysfunction induced by hemodynamic overloading were greater in DCKO mice than in mice with a single deletion of either PKCδ or PKCε. Furthermore, gene expression analysis of the hearts of DCKO mice revealed transcriptional derepression of the genes encoding the kinase ERK (extracellular signal–regulated kinase) and periostin. Mice with combined embryonic ablation of PKCδ and PKCε showed enhanced growth and cardiomyocyte hyperplasia that induced pathological ventricular stiffening and early lethality, phenotypes absent in mice with a single deletion of PKCδ or PKCε. Our results indicate that novel PKCs provide retrograde feedback inhibition of growth signaling pathways central to cardiac development and stress adaptation. These growth-suppressing effects of novel PKCs have implications for therapeutic inhibition of PKCs in cancer, heart, and other diseases.  
stke.sciencemag.org
almost 6 years ago