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Genome Editing with CRISPR-Cas9

This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease.  
youtube.com
over 6 years ago
Musclegenes
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Do you have the "fat gene" and can you beat it? Dr. Daniel Reardon, co-founder of MuscleGenes is on the case...

MuscleGenes has been chosen to partner with leading sports science researchers at Loughborough University on the FTO gene. This research will further our understanding of the fundamental question, "Am I genetically programmed to be overweight?"  
finance.yahoo.com
over 6 years ago
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Can anyone guide me to the latest advances in gene therapy for ataxia with oculomotor apraxia type 2?

Gene therapy or stem cell therapy for ataxia #Neurology #Genetics  
Aasia
over 6 years ago
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Genetics and Parkinson's disease

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or (http://www.khanacademy.org/test-prep/mcat) for MCAT...  
youtube.com
over 6 years ago
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The role of pathogen genomics in assessing disease transmission

Whole genome sequencing (WGS) of pathogens enables the sources and patterns of transmission to be identified during specific disease outbreaks and promises to transform epidemiological research on communicable diseases. This review discusses new insights into disease spread and transmission that have come from the use of WGS, particularly when combined with genomic scale phylogenetic analyses. These include elucidation of the mechanisms of cross species transmission, the potential modes of pathogen transmission, and which people in the population contribute most to transmission. Particular attention is paid to the ability of WGS to resolve individual patient to patient transmission events. Importantly, WGS data seem to be sufficiently discriminatory to target cases linked to community or hospital contacts and hence prevent further spread, and to investigate genetically related cases without a clear epidemiological link. Approaches to combine evidence from epidemiological with genomic sequencing observations are summarised. Ongoing genomic surveillance can identify determinants of transmission, monitor pathogen evolution and adaptation, ensure the accurate and timely diagnosis of infections with epidemic potential, and refine strategies for their control.  
feeds.bmj.com
over 6 years ago
Www.bmj
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The role of pathogen genomics in assessing disease transmission

Whole genome sequencing (WGS) of pathogens enables the sources and patterns of transmission to be identified during specific disease outbreaks and promises to transform epidemiological research on communicable diseases. This review discusses new insights into disease spread and transmission that have come from the use of WGS, particularly when combined with genomic scale phylogenetic analyses. These include elucidation of the mechanisms of cross species transmission, the potential modes of pathogen transmission, and which people in the population contribute most to transmission. Particular attention is paid to the ability of WGS to resolve individual patient to patient transmission events. Importantly, WGS data seem to be sufficiently discriminatory to target cases linked to community or hospital contacts and hence prevent further spread, and to investigate genetically related cases without a clear epidemiological link. Approaches to combine evidence from epidemiological with genomic sequencing observations are summarised. Ongoing genomic surveillance can identify determinants of transmission, monitor pathogen evolution and adaptation, ensure the accurate and timely diagnosis of infections with epidemic potential, and refine strategies for their control.  
feeds.bmj.com
over 6 years ago
Cfd2e371ff69ee30497aab8712168b9941e69e65592577899768066
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Antibiotics summary

Classifications of antibiotics - a useful summary. The Table is no way complete. Kindly Ignore Spelling mistakes Checkout mynotes4usmle.tumblr.com for more  
Sarosh Kamal
over 6 years ago
C52ce64efe5f6aa4fa05c1c40e97b5580633bfdc4162097039029059
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Renal Tubular Defects - Site of Condition

- Fanconi (“Fan-of-cones”) syndrome: reabsorptive defects in the proximal convoluted tubule - Bartter (“Bart”) syndrome: reabsorptive defect in thick ascending loop of Henele - Gitelman (“Giggle-man”) syndrome: reabsorptive defect of NaCl in distal convoluted tubule - Liddle (“Chicken Little”) syndrome: increased sodium reabsorption in the collecting tubules  
Ryan Matthews
over 6 years ago
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A Conversation with Oxford's Peter Donnelly: Genomics and Personalized Medicine

The TDWI/Hatch team had good fortune to attend the amazing Personalized Medicine World Conference put on by Tal and Gadi Behar at the Computer History Museum...  
youtube.com
over 6 years ago
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Gigantic Data and Genomics

Pat Salber (@docweighsin) chats with Oracle's Jonathan Sheldon (Global VP for Health Care) about meeting the data demands of Precision Medicine. He says that...  
youtube.com
over 6 years ago
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Gigantic Data and Genomics - YouTube

Pat Salber (@docweighsin) chats with Oracle's Jonathan Sheldon (Global VP for Health Care) about meeting the data demands of Precision Medicine. He says that...  
youtube.com
over 6 years ago
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Radiation for brain metastases, and the genetics of ischaemic stroke

Stream Radiation for brain metastases, and the genetics of ischaemic stroke by BMJ talk medicine from desktop or your mobile device  
feeds.bmj.com
over 6 years ago
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Lipids Blamed for Coronary Risk With Short Stature

Implicated as a substantial factor behind the association in genetics study.  
medpagetoday.com
over 6 years ago
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Genes May Leave Short People Prone to Heart Disease - MedicineNet

Short people may be more likely to have heart disease, and that increased risk could be linked to the genetics that also determine height, a British-led research team suggests.  
medicinenet.com
over 6 years ago
Ts 140724 dialysis machine 800x600
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Genetics Ups Risk of Cardiac Arrest in Dialysis Patients

Genetic factors appear to significantly increase the risk for sudden cardiac death among patients receiving dialysis.  
medscape.com
over 6 years ago
Is 150415 genotyping 800x600
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Precision Medicine Needs 'Precision Genomics'

In half of all cancer patients, tumor-only gene sequencing is not enough to guide therapeutic decisions on the use of precision cancer agents.  
medscape.com
over 6 years ago
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Can Genetics Predict Coronary Heart Disease Risk? CME/CE

: A new analysis of primary and second prevention studies shows that a genetic risk profile helps identify those at risk for coronary heart disease and those who would benefit from statins.  
medscape.org
over 6 years ago
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Myriad RBN joins Institut Pasteur in the global fight against tuberculosis

Myriad RBM, a wholly owned subsidiary of Myriad Genetics, Inc. has announced that it will assist the Institut Pasteur in a public-private research collaboration to fight the global...  
medicalnewstoday.com
over 6 years ago
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CRISPR-Cas editing of C. albicans holds promise for overcoming deadly fungal infections

By modifying the CRISPR-Cas genome editing system, Whitehead Institute researchers are now able to manipulate Candida albicans' genome systematically--an approach that could help identify novel...  
medicalnewstoday.com
over 6 years ago
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Myriad announces Prolaris test biopsy results from EMPATHY-P study at European Association of Urology annual meeting

Myriad Genetics, Inc. has announced that results from the EMPATHY-P clinical study of Prolaris in patients newly diagnosed with prostate cancer will be highlighted at the 30th Annual Congress...  
medicalnewstoday.com
over 6 years ago