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CysticFibrosis

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Cystic fibrosis

This podcast tutorial on cystic fibrosis gives an overview of the disease including presentation and diagnosis.  
Mr Raymond Buick
about 10 years ago
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How important is Aspergillus in cystic fibrosis? by Rick Moss

Cystic fibrosis (CF) occurs in 1 in 4,000 births, and there are approximately 70,000 people worldwide who have CF. Aspergillus lung infection is often found in people with CF, is more common in adults and becomes increasingly common as lung function declines.  
Aspergillus Website
about 8 years ago
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Cystic Fibrosis (CF)

This is the most common life-limiting inherited disease in Caucasians. It is caused by a genetic mutation that alters mucus production, resulting in a more viscous solution. It is autosomal recessive.   Life expectancy is improving. Newborns with CF have a life-expectancy of about 40 years. The condition is inherited in an autosomal recessive pattern.   Epidemiology Most common in Caucasians, rare in other races.    
almostadoctor.com - free medical student revision notes
over 4 years ago
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Journal club: Azithromycin and increased mycobacterial infections in cystic fibrosis patients

Stream Journal club: Azithromycin and increased mycobacterial infections in cystic fibrosis patients by BMJ talk medicine from desktop or your mobile device  
SoundCloud
over 3 years ago
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Aspergillus and Human Health

Many may be familiar with aspergillosis as the infecting agent in acute cases where the patient is severely immunocompromised - but there is more to this fungus' repertoire. There are rare cases where the patient's immune system is overwhelmed by a large inhalation of spores e.g. after gardening, but these are insignificant in terms of total numbers effected. The following are far more common:- Aspergillus and other fungi are increasingly identified as the active agent in sinusitis - if you have cases that don't respond to antibiotics this is worth thinking about. Chronic pulmonary aspergillosis (CPA & aspergilloma) is an infection of immunocompetent people, causing respiratory difficulty, coughing and haemoptysis. The UK NHS has a specialist centre for these patients In Manchester (National Aspergillosis Centre (NAC)). NAC has particular expertise and extensive facilities for the diagnosis of CPA, ABPA, SAFS and use of systemic antifungal drugs. Allergic infection (Allergic Bronchopulmonary Aspergillosis - ABPA and chronic sinusitis) is thought to be heavily underdiagnosed and undertreated. ABPA is particularly common in Asthma, Cystic Fibrosis patients and those with bronchiectasis. There is estimated to be 25 000 cases in the UK alone. Many (50%) of the most severe asthma cases are sensitive to fungi (SAFS) - in particular Aspergillus. These tend to be the most unstable cases that don't respond to antibiotics and several studies have been published that show giving an antifungal helps reduce the use of steroids for these patients. Last but not least - Tuberculosis is on the rise in the UK and the rest of the world. It is estimated that 2% of cases progress to CPA and should be treated using an antifungal - this is usually not done until considerable time has passed and much damage has been done. In total it is estimated that many millions of people across the world suffer from aspergillus - ABPA - 5 million, Tb - 400 000 per year and Asthma (SAFS - 1 - 4 million cases in EU & US). Sinusitis cases may number many tens of millions worldwide. So - the next time you assume aspergillus infections and aspergillosis are rare and confined to those who are profoundly immunocompromised - think again! If you have a patient who has increasingly severe respiratory symptoms, doesn't respond to multiple courses of antibiotics then give aspergillus a thought. Browse around these articles for further information Aspergillus Website Treatment Section. NB For a broader look at the prevalence of fungal diseases worldwide the new charity Leading International Fungal Education (LIFE) website is worth looking at.  
Graham Atherton
over 5 years ago
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Cystic fibrosis boy's Facebook pills video gets 650,000 hits - BBC News

An online video of a six-year-old boy swallowing tablets for cystic fibrosis is viewed more than 650,000 times.  
bbc.co.uk
over 3 years ago
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Cystic Fibrosis with Dr. O'Hagan

Dr. O'Hagan is an Assistant Professor with joint appointments with Pediatrics and Pulmonary and Critical Care Medicine. Dr. O'Hagan has specific interest in ...  
youtube.com
over 3 years ago
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Unraveling cystic fibrosis puzzle, taking it personally matters

In the genetic disorder cystic fibrosis (CF), the most severe symptoms are recurring episodes of lung inflammation and bacterial infection (known as 'exacerbations') that happen from one to...  
medicalnewstoday.com
over 3 years ago
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New cystic fibrosis research could help develop treatments to improve muscle function

People suffering from cystic fibrosis have less ability to uptake and use oxygen in their muscles, which leads to exercise intolerance, a study published in Experimental Physiology...  
medicalnewstoday.com
over 3 years ago
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Publicly insured Americans 'have poorer lung transplantation survival' than UK patients

A new study reveals that publicly insured US patients who undergo lung transplantation for cystic fibrosis have poorer survival than publicly insured UK patients.  
medicalnewstoday.com
over 3 years ago
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Cystic fibrosis research to benefit from lab-grown 'mini-lungs'

Using stem cells derived from patients' skin cells, scientists have made organoids of airway lung tissue that should be more reliable than mice for cystic fibrosis research.  
medicalnewstoday.com
over 3 years ago
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Scientists grow 'mini-lungs' to aid the study of cystic fibrosis

Scientists at the University of Cambridge have successfully created 'mini-lungs' using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be...  
medicalnewstoday.com
over 3 years ago
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Dramatic rise expected in adults living with cystic fibrosis

The number of people living with cystic fibrosis into adulthood is expected to increase dramatically by 2025, prompting calls for the development of adult cystic fibrosis services to meet the...  
medicalnewstoday.com
over 3 years ago
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Study may explain low blood oxygen for cystic fibrosis patients with infected lungs

Researchers have defined a new bodily process in mice that may explain why blood oxygen levels are lower for patients with cystic fibrosis when they get a lung infection.  
medicalnewstoday.com
over 3 years ago
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New cystic fibrosis research takes aim at deadly pathogen

A new method of testing the most common cause of life-threatening infection in people with cystic fibrosis could improve efforts to study and combat the illness.  
medicalnewstoday.com
over 3 years ago
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Research could be 'life-prolonging' for cystic fibrosis patients

Preventing lung infections in childhood could stop later life-threatening infections for people with cystic fibrosis (CF), according to the latest research carried out at Aston University.  
medicalnewstoday.com
over 3 years ago
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Garlic extract could help cystic fibrosis patients fight infection

A chemical found in garlic can kill bacteria that cause life-threatening lung infections in people with cystic fibrosis, research suggests.  
medicalnewstoday.com
over 3 years ago
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Researchers pin down genetic pathways linked to CF disease severity

New findings from the UNC School of Medicine may shed light on why cystic fibrosis patients with the same genetic mutation can have different disease severity and may react differently to...  
medicalnewstoday.com
over 3 years ago
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Altered microbiome linked to liver disease in adolescents with cystic fibrosis

A professor at the University of Colorado School of Medicine at the Anschutz Medical Campus and his colleagues have found a possible cause of liver disease in adolescents with cystic fibrosis.  
medicalnewstoday.com
over 3 years ago