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BiomedicalResearch

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Critical Care

A substantial number of patients admitted to the ICU because of an acute illness, complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle weakness during the ICU stay that is referred to as “intensive care unit acquired weakness” (ICUAW). This ICUAW evoked by critical illness can be due to axonal neuropathy, primary myopathy, or both. Underlying pathophysiological mechanisms comprise microvascular, electrical, metabolic, and bioenergetic alterations, interacting in a complex way and culminating in loss of muscle strength and/or muscle atrophy. ICUAW is typically symmetrical and affects predominantly proximal limb muscles and respiratory muscles, whereas facial and ocular muscles are often spared. The main risk factors for ICUAW include high severity of illness upon admission, sepsis, multiple organ failure, prolonged immobilization, and hyperglycemia, and also older patients have a higher risk. The role of corticosteroids and neuromuscular blocking agents remains unclear. ICUAW is diagnosed in awake and cooperative patients by bedside manual testing of muscle strength and the severity is scored by the Medical Research Council sum score. In cases of atypical clinical presentation or evolution, additional electrophysiological testing may be required for differential diagnosis. The cornerstones of prevention are aggressive treatment of sepsis, early mobilization, preventing hyperglycemia with insulin, and avoiding the use parenteral nutrition during the first week of critical illness. Weak patients clearly have worse acute outcomes and consume more healthcare resources. Recovery usually occurs within weeks or months, although it may be incomplete with weakness persisting up to 2 years after ICU discharge. Prognosis appears compromised when the cause of ICUAW involves critical illness polyneuropathy, whereas isolated critical illness myopathy may have a better prognosis. In addition, ICUAW has shown to contribute to the risk of 1-year mortality. Future research should focus on new preventive and/or therapeutic strategies for this detrimental complication of critical illness and on clarifying how ICUAW contributes to poor longer-term prognosis.  
ccforum.com
over 5 years ago
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Can apps be used for the delivery of survey questionnaires in public health and clinical research? | Cochrane

Survey questionnaires are important tools in public health and clinical research as they offer a convenient way of collecting data from a large number of respondents, dealing with sensitive topics, and are less resource intensive than other data collection techniques. The delivery of survey questionnaires via apps running on smartphones or tablets could maximise the scalability and speed of data collection offered by these tools, whilst reducing costs. However, before this technology becomes widely adopted, we need to understand how it could affect the quality of the responses collected. Particularly, if we consider the impact that data quality can have on the evidence base that supports many public health and healthcare decisions.  
cochrane.org
over 5 years ago
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10

Cerebral mass in HIV infection

A 34 year old woman from the Republic of Congo with known HIV infection presented with a one day history of sudden weakness of the right arm and mild headache. She had a history of cardiomyopathy, hypertension, and epilepsy. She had not travelled abroad since she had moved to the United Kingdom 10 years ago. Other than weakness in the extensor muscles of the right arm grade 4/5 on the Medical Research Council scale, the physical examination was unremarkable.  
feeds.bmj.com
over 5 years ago
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The North West Emergency Medicine Regional Research Symposium 2015 - St.Emlyn's

North West Emergency Medicine Regional Research Symposium: Formerly known as Culyer Day, this event celebrates the great clinical research in our specialty.  
feedproxy.google.com
over 5 years ago
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The North West Emergency Medicine Regional Research Symposium 2015 - St.Emlyn's

North West Emergency Medicine Regional Research Symposium: Formerly known as Culyer Day, this event celebrates the great clinical research in our specialty.  
stemlynsblog.org
over 5 years ago
Www.bmj
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Planned Parenthood accuses anti-abortion group of “corporate espionage” for promoting misleading video

The Planned Parenthood Federation of America this week warned that an undercover video edited to suggest wrongly that the group sold fetal body parts for profit may be the first of many, as the group that released it has been posing as a legitimate biomedical research supply firm for three years.  
feeds.bmj.com
over 5 years ago
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5
123

Genome Editing with CRISPR-Cas9

This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease.  
youtube.com
over 5 years ago
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7

Research is stifled by “regulation and conservatism,” conference hears

The medical research community has failed to respond to the threat of infectious diseases, Jeremy Farrar, director of the Wellcome Trust, has warned. Speaking in London at the scientific conference for charity Médecins Sans Frontières, Farrar said that medical research was stifled by regulation and conservatism and hampered by fragmentation.  
feeds.bmj.com
almost 6 years ago
Www.bmj
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Research is stifled by “regulation and conservatism,” conference hears

The medical research community has failed to respond to the threat of infectious diseases, Jeremy Farrar, director of the Wellcome Trust, has warned. Speaking in London at the scientific conference for charity Médecins Sans Frontières, Farrar said that medical research was stifled by regulation and conservatism and hampered by fragmentation.  
feeds.bmj.com
almost 6 years ago
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Aarkstore — Stem Cell Research in Cardiology

Aarkstore.com announces, The Latest market research report is available in its vast collection “Stem Cell Research in Ca…  
medium.com
almost 6 years ago
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13

Cambodia Oxford Medical Research Unit (COMRU): Our work at Angkor Hospital for Children

This video introduces COMRU, the Cambodia Oxford Medical Research Unit, a collaboration set up between the Angkor Hospital for Children, a paediatric NGO-fun...  
youtube.com
almost 6 years ago
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Cambodia Oxford Medical Research Unit (COMRU): Our work at Angkor Hospital for Children - YouTube

This video introduces COMRU, the Cambodia Oxford Medical Research Unit, a collaboration set up between the Angkor Hospital for Children, a paediatric NGO-fun...  
youtube.com
almost 6 years ago
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20

SGEM#52: Breakfast at Glenfield – Asthma, Social Media and Knowledge Translation

Podcast Link: SGEM52 Date:  November 7, 2013 Title: Breakfast at Glenfield – Asthma, Social Media and Knowledge Translation  
thesgem.com
almost 6 years ago